The mechanisms of alloxan- and streptozotocin-induced diabetes
نویسندگان
چکیده
منابع مشابه
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present with malformed fetuses, there is great interest in understanding the etiology, pathophysiological mechanisms, and treatment of gestational diabetes. Hyperglycemia enhances the production of reactive oxygen species, leading t...
متن کاملEffector Mechanisms in Low-Dose Streptozotocin-induced Diabetes
The cellular and molecular requirements for beta-cell damages in an immune-mediated toxin-induced insulin-dependent diabetes mellitus have been studied in the model of multiple low-dose streptozotocin-induced diabetes in rats and mice. It was found that strain-related susceptibility to diabetes induction correlated with a higher level of IL-2, IFN-gamma, and TNF-alpha production, whereas such d...
متن کاملThe Ultrastructural Changes of the Sertoli and Leydig Cells Following Streptozotocin Induced Diabetes
Objective(s) This investigation was conducted to evaluate the effects of diabetes on the structure and function of testicular tissue. Materials and Methods Diabetes was induced in male adult rats by a single intraperitoneal injection of streptozotocin. Body and testicular weight, hormonal analyses, histological and ultrastructural analyses were measured. Results The body and testicular we...
متن کاملThe effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
Diabetes is one of the most common diseases in all societies including Iran. One of its important complications is the neuropathic pain, which can be relieved by opioid drugs such as morphine. Opioid therapy is restricted due to development of tolerance and physical or mental dependence. In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and depend...
متن کاملThe effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
Diabetes is one of the most common diseases in all societies including Iran. One of its important complications is the neuropathic pain, which can be relieved by opioid drugs such as morphine. Opioid therapy is restricted due to development of tolerance and physical or mental dependence. In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and depend...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2007
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-007-0886-7